With the advent of CRISPR technologies. almost at any specific locus in any genome of animal or plant. large-size DNA fragment can be inserted or replaced seamlessly following the occurrence of CRISPR nuclease-produced double-strand break (DSB) and donor DNA. and the induction of homology-directed repair (HDR) can be realized. https://www.royaltyfurnitureandappliancers.shop/product-category/grandfather-clocks/